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AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg is approved by the U.S. Food and Drug Administration (FDA) to help improve walking in adult patients with multiple sclerosis (MS). This was demonstrated by an increase in walking speed.

AMPYRA is the first and only branded prescription MS therapy that has been specifically approved by the FDA for this use. More than 400,000 people in the U.S. and nearly 2.5 million people worldwide are living with MS, and for the majority of those people, the disease affects their ability to walk. Walking difficulties can happen to anyone with MS, and can lead to difficulty in keeping up with family and friends, or having difficulty crossing the street. We are gratified to have been able to contribute to advancing the care of people with MS.

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Important Safety Information

Do not take AMPYRA if you have ever had a seizure, have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Take AMPYRA exactly as prescribed by your doctor.

Before taking AMPYRA, tell your doctor if you

  • have kidney problems or any other medical conditions
  • are taking compounded 4-aminopyridine
  • are taking any other prescription or OTC medicines, such as cimetidine
  • are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if AMPYRA passes into your breast milk. You and your doctor should decide if you will take AMPYRA or breast-feed. You should not do both.

Stop taking AMPYRA and call your doctor right away if you have a seizure while taking AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50. Your doctor may do a blood test to check how well your kidneys are working before you start AMPYRA.

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP, fampridine), since the active ingredient is the same.

AMPYRA may cause serious side effects, including severe allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives.

The most common side effects for AMPYRA in MS patients were urinary tract infection; trouble sleeping; dizziness; headache; nausea; weakness; back pain; problems with balance; multiple sclerosis relapse; burning, tingling or itching of your skin; irritation in your nose and throat; constipation; indigestion; and pain in your throat.

Please see Patient Medication Guide for additional safety information.

AMPYRA is a registered trademark of Acorda Therapeutics, Inc.
AMPYRA is marketed by Acorda Therapeutics, Inc. and manufactured under license from Alkermes Pharma Limited (APIL), Ireland.

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