ZANAFLEX CAPSULES is a short-acting drug for the management of spasticity. Because of the short duration of effect, treatment with tizanidine should be reserved for those daily activities and times when relief of spasticity is most important. Spasticity is a frequent and often significant consequence of injuries to the central nervous system, including multiple sclerosis (MS), spinal cord injury (SCI), brain trauma and stroke. People with spasticity can suffer severe, painful muscle spasms and/or rigidity during the day and night. ZANAFLEX CAPSULES are thought to reduce spasticity by blocking nerve impulses through pre-synaptic inhibition of motor neurons, which decreases spasticity without reducing muscle strength.
While ZANAFLEX CAPSULES and ZANAFLEX® (tizanidine hydrochloride) TABLETS both contain tizanidine hydrochloride, ZANAFLEX CAPSULES are not the same as or bioequivalent to generic tizanidine tablets or ZANAFLEX TABLETS. Food has a complex effect on how tizanidine is absorbed and processed in the body, so ZANAFLEX CAPSULES are not interchangable with ZANAFLEX TABLETS or generic tizanidine tablets.
A person’s experience taking ZANAFLEX CAPSULES may change depending on whether or not this medication is taken with or without food, including potential changes in efficacy and side effects. It is important that patients follow their doctor’s instructions on how to take this medication.
ZANAFLEX CAPSULES are available in 2-mg, 4-mg and 6-mg strengths.
ZANAFLEX CAPSULES can give physicians and patients greater flexibility in managing spasticity. Some patients may find capsules easier to take than tablets and, for patients who have an impaired ability to swallow, capsules can be opened and sprinkled on soft foods such as applesauce. This is not bioequivalent to administration of an intact capsule. In addition, the 6-mg dose, which is not available in a tablet form, may provide the opportunity for patients to take fewer pills per day.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/, or call 1-800-FDA-1088.
ZANAFLEX CAPSULES® and ZANAFLEX® are registered trademarks of Acorda Therapeutics, Inc.